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KMID : 0880220120500040665
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Journal of Microbiology
2012 Volume.50 No. 4 p.665 ~ p.672
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Probing the ArcA regulon in the rumen bacterium Mannheimia succiniciproducens by genome-wide expression profiling
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Yun Seul-gi
Shin Jong-Moon
Kim Oh-Cheol
Jung Young-Ryul
Oh Doo-Byoung
Kwon Oh-Suk
Lee Sang-Yup
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Abstract
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In this study, the putative target genes of the Arc two-component system of the rumen bacterium Mannheimia succiniciproducens were determined by analyzing the transcriptome of the ArcA overexpression strain and by the in silico scanning of the entire genome sequence with the position weight matrix of the ArcA binding sequence developed for Escherichia coli. The majority of 79 repressed genes were involved in energy metabolism and carbohydrate transport and metabolism, while the majority of 82 induced genes were involved in hypothetical or unknown functions. Our results suggest that the Arc system in M. succiniciproducens has a specific function that differs from that in E. coli.
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KEYWORD
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two-component signal transduction system, ArcA response regulator, target genes, Mannheimia succiniciproducens
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